Bromo-DragonFLY

From Freepedia

Bromo-DragonFLY
Chemical name	Bromo-benzodifuranyl-isopropylamine or (1-(8-bromobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane
Chemical formula	C13H12BrNO2
Molecular mass	294.15 g/mol
Melting point	decomposes at 240 °C (hydrochloride)
CAS number	-
SMILES	N[C@H](C)CC1=C(OC=C2)C2=C(Br)C3=C1C=CO3 (R-isomer)
Image:R-Bromo-DragonFLY.png

Bromo-DragonFLY is a psychedelic hallucinogenic drug somewhat related to the phenethylamine family. Bromo-DragonFLY is considered an extremely potent hallucinogen, comparable in dosage to LSD, and it has an extremely long duration of action. Bromo-DragonFLY has a stereocenter and R-(-)-bromo-DragonFLY is the more active stereoisomer.

Contents 1 Pharmacology 2 History 3 See also 4 References 5 Categorization

Pharmacology

The hallucinogenic effect of bromo-DragonFLY is mediated by its partial agonistic activity at the 5-HT_2A serotonin receptor, but bromo-DragonFLY also has a high binding affinity for the 5-HT_2B and 5-HT_2C serotonin receptor.

History

Bromo-DragonFLY was first synthesized by Matthew A. Parker in the laboratory of David E. Nichols in 1998.

See also

• DOB
• PiHKAL

References

• 'A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT_2A receptor' by M. A. Parker, D. Marona-Lewicka, V. L. Lucaites, D. L. Nelson, and D. E. Nichols in J. Med. Chem. 41(26): 5148-5149 (1998) DOI: 10.1021/jm9803525

• 'Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT_2A/2C receptor agonists' by J. J. Chambers, D. M. Kurrasch-Orbaugh, M. A. Parker, and D. E. Nichols in J. Med. Chem. 44(6): 1003-1010 (2001) DOI: 10.1021/jm000491y

Categorization