Dextroamphetamine

From Freepedia

Dextroamphetamine (also known as dextroamphetamine sulfate, dexamphetamine, Dexedrine, Dextrostat, Dexampex, Ferndex, Oxydess II, Robese, Spancap #1, and, informally, Dex), a stereoisomer of amphetamine, is an indirect-acting stimulant that releases norepinephrine from nerve terminals, thus promoting nerve impulse transmission. It increases motor activity and mental alertness, and reduces drowsiness and a sense of fatigue, decreasing motor restlessness and improves one's ability to focus. The drug comes in 5 mg and 10 mg tablets, or tabs. In some places, it is also found in dosages up to 15 mg, although only one of these pills is recommeneded in the body at any one time.

Its only accepted indications are for children and adults with attention deficit hyperactivity disorder (ADHD) or well-established narcolepsy, generally where non-pharmacological measures have proved insufficient. In some localities it has replaced Ritalin as the first-choice pharmacological treatment of ADHD, of which it is considered an effective treatment. Dexedrine is contraindicated for patients with a history of substance abuse.

Certain studies have been performed regarding possible alternate use for antidepressant treatment for HIV patients with depression and debilitating fatigue, early stage physiotherapy for severe stroke victims and treatment for those with methamphetamine (speed) addiction.

Possible adverse effects of dexamphetamine include insomnia, reduced appetite, dependence, nervousness, restlessness, irritability, and euphoria that may be followed by fatigue and depression. There may be dryness of mouth, abdominal cramps, headache, dizziness, tremor, sweating, palpitations, increased or sometimes decreased blood pressure and altered libido. The Physician's 1991 Drug Handbook reports: "Symptoms of overdose include restlessness, tremor, hyperreflexia, tachypnea, confusion, aggressiveness, hallucinations, and panic."

The US Air Force uses Dexedrine as its "go-pill". It is given to pilots on long missions to help them remain focused and alert. However, Dexedrine is being phased out in favor of Provigil as the Air Force's new go-pill

There have also been reports of growth retardation of children with long-term use, although this effect can be reduced by alternating periods of abstinence from dexedrine.

Dexedrine and literature

• Dexys Midnight Runners derives their name from this drug.

• Allen Ginsberg was a frequent user of amphetamines, including Dexedrine. When he died, pundit George Will wrote of his most famous poem, published in 1956: "He composed 'Howl' with the help of a cocktail of peyote, amphetamines and Dexedrine" (Washington Post, April 9, 1997).

• Steven Watson, in The Birth of the Beat Generation (2002), reports that Jack Kerouac died in 1967 "addicted to Johnny Walker Red and Dexedrine." [1]

• In Robert Stone's novel A Flag for Sunrise (1981), Pablo Tabor, an amphetamine-addicted user of Dexedrine, among other drugs, is an important character.

• Jim Bouton makes mention of Dexedrine use in Major League Baseball (under the street name "greenies") in his book Ball Four (1970).

• Tom Clancy's book Net Force (1998) also mentions the compound, referring to it as "dexadrine".

• Michael Herr's book Dispatches (1968) tells of a soldier in the Vietnam War using Dexedrine.

• The Rolling Stones' song Mother's Little Helper is referring to Dexedrine.

References

• http://www.mentalhealth.com/drug/p30-d04.html
• http://www.gpnotebook.co.uk/cache/1845887055.htm
• http://amphetamines.com/dextroamphetamine/
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14520168&dopt=Abstract
• http://www.medsafe.govt.nz/Profs/Datasheet/d/Dexamphetaminesulphatetab.htm
• http://www.websters-online-dictionary.org/definition/english/De/Dextroamphetamine.html

See also

• ADHD
• amphetamine
• benzedrine
• ephedrine
• methamphetamine
• pseudoephedrine
• methylphenidate (Ritalin®)