Metabolome

From Freepedia

Metabolome^[1] is the whole set of metabolic entities and small pathway motifs in a cell, tissue, organ, organisms, and species.

The metabolome includes proteins, RNA, DNA and various substrates. It also includes small circuits of pathway networks. The very large portion of metabolome study has been metabolic engineering to produce industrially meaningful compounds.

See also

• Metabolomics
• Mass spectrometry | 2D gel | Protein sequencing.
• Databases: PIR | Swissprot | Pfam
• Bioinformatics

External links

• Proteome.org
• Bioinformatics Journal

References

1. ^  First use of the term "metabolome" in the literature — Oliver, S. G., Winson, M. K., Kell, D. B. & Baganz, F. (1998). Systematic functional analysis of the yeast genome. Trends Biotechnol. 16 (10): 373–378. PMID 9744112.
2. First book on metabolomics — {{{Author|}}}{{|{{{3}}}}}}|show1| (2003)}}{{{{{Year|}}}}}}|show1|.}} {{|{{{3}}}}}}|show1|[{{{URL}}}}} RMetabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis{{|{{{3}}}}}}|show1|]}}{{|{{{3}}}}}}|show1|, {{{Pages}}}}}{{|{{{3}}}}}}|Show1|, Kluwer Academic Publishers (Boston)}}. {{{ID|}}}
3. Fiehn, O., Kloska, S. & Altmann, T. (2001). Integrated studies on plant biology using multiparallel techniques. Curr. Opin. Biotechnol. 12 (1): 82–86. PMID 11167078.
4. Fiehn, O. (2001). Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks.. Comp. Funct. Genomics 2 (3): 155–168. Publisher abstract link

• Weckwerth, W. Metabolomics in systems biology. Annu. Rev. Plant Biol. 54, 669–689 (2003).
• Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G. & Kell, D. B. Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol. 22, 245–252 (2004).
• Nicholson, J. K., Holmes, E., Lindon, J. C. & Wilson, I. D. The challenges of modeling mammalian biocomplexity. Nature Biotechnol. 22, 1268–1274 (2004). Stresses the role of intestinal microorganisms in contributing to the human metabolome.
• van der Greef, J., Stroobant, P. & van der Heijden, R. The role of analytical sciences in medical systems biology. Curr. Opin. Chem. Biol. 8, 559–565 (2004).
  • The importance of analytical sciences to omics and systems biology.
• Kell, D. B. Metabolomics and systems biology: making sense of the soup. Curr. Opin. Microbiol. 7, 296–307 (2004).
  • Metabolomic data as an input to systems biology models.