NADH dehydrogenase
From Freepedia
Image:Ubiquinone-1BE3.png NADH dehydrogenase (EC 1.6.5.3), Complex I of the mitochondrial electron transfer chain, catalyzes the transfer of electrons from NADH to coenzyme Q (CoQ)
- 2NADH + CoQ + 2H+ → 2NAD+ + CoQH2
In the process, the complex also translocates protons across the inner membrane, helping to build the electrochemical potential used to produce ATP.
It is the largest of the respiratory complexes, the mammalian enzyme containing 46 separate protein subunits. Of particular functional importance are the flavin prosthetic group and eight iron-sulfur clusters. Of the 46 subunits, seven are encoded by the mitochondrial genome.
Defects in the subunits of Complex I are associated with various mitochondrial diseases, including Leigh syndrome and Parkinson's disease.
Amytal and rotenone inhibit the transfer of electrons from Complex I (NADH dehydrogenase) to Complex III (Coenzyme Q - cytochrome c reductase complex).
More information can be found on the Complex I home page.
