Richard Doll

From Freepedia

Professor Sir William Richard Shaboe Doll, KBE CH FRS (28 October 1912–24 July 2005) was a British epidemiologist, physiologist, and a pioneer in the research linking smoking to health problems. He was the first in the world to prove that smoking caused lung cancer and increased the risk of heart disease. He also did pioneering work on the relationship between radiation and leukemia as well as that between asbestos and lung cancer.

Contents

Biography

Doll was born at Hampton into an affluent family, though his father's work at a doctor was cut short by multiple sclerosis. Educated first at Westminster School, Doll originally then intended (against the wishes of his parents that he become a doctor like his father) to study mathematics at Trinity College, Cambridge. Reportedly, Doll failed the math scholarship exam due to drinking too much Trinity College homebrew beer the night before. He subsequently chose to study medicine at St. Thomas's Hospital from where he graduated in 1937, Doll joined the Royal College of Physicians after the outbreak of World War II and served for much of the war as a part of the Royal Army Medical Corps on a hospital ship as a medical specialist.

After the war, Doll returned to St. Thomas's to research asthma. In 1948 he joined a research team under Dr. Francis Avery-Jones at the Central Middlesex Hospital, run under the auspices of the statistical research unit of the Medical Research Council. Over a 21 year career in the unit, Doll rose to become its director. His research there initially consisted of disproving the then-held belief that peptic ulceration was caused by heavy responsibility, but instead stress. In 1950, he then undertook with Austin Bradford Hill a study of lung cancer patients in 20 London hospitals, at first under the belief that it was due to the new material tarmac, or motor car fumes, but rapidly discovering that tobacco smoking was the only factor they had in common. Doll himself stopped smoking as a result of his findings, published in the British Medical Journal in 1950, which concluded;

"The risk of developing the disease increases in proportion to the amount smoked. It may be 50 times as great among those who smoke 25 or more cigarettes a day as among non-smokers."

Four years later, in 1954 the British doctors study, a study of some 40 thousand doctors over 20 years, confirmed the suggestion, based on which the government issued advice that smoking and lung cancer rates were related.

In 1966 Doll was elected to the Royal Society. The citation stated;

Doll is distinguished for his researches in epidemiology & particularly the epidemiology of cancer where in the last 10 years he has played a prominent part in (a) elucidating the causes of lung cancer in industry (asbestos, nickel & coal tar workers) & more generally, in relation to cigarette smoking, and (b) in the investigation of leukaemia particularly in relation to radiation, where using the mortality of patients treated with radiotherapy he has reached a quantitative estimate of the leukaemogenic effects of such radiation. In clinical medicine he has made carefully controlled trials of treatments for gastric ulcer. He has been awarded the United Nations prize for outstanding research into the causes & control of cancer & the Bisset Hawkins medal of the Royal College of Physicians for his contributions to preventative medicine

In 1969, Doll moved to Oxford University, to sit as the Regius Professor of Medicine, succeeding the clinical researcher Sir George Pickering.

Initially, epidemiology was held in low regard, but in his time at Oxford he helped reverse this. He was the primary agent behind the creation of Green College, a medical-only college, from where he retired in 1983.

Doll also helped found the National Blood Service, and was key in avoiding a system of paying donors for their blood, as had been adopted in the United States. His continued work into carcinogens at the Imperial Cancer Research Center, working as part of the Clinical Trial Service Unit at Oxford, notably including a study undertaken with Sir Richard Peto, in which it was estimated that tobacco, along with infections and diet, caused between then three quarters of all cancers, which was the basis of much of the World Health Organisation's conclusions on environmental pollution and cancer. Other work included suggestions that aspirin can help avoid heart disease, and that binge-drinking may be linked to breast cancer.

Doll was Knighted in 1971, and made a Companion of Honour in 1996 for "services of national importance". He was made a Fellow of the Royal Society, awarded the Presidential Award of the New York Academy of Sciences as well as a UN Award for his research into cancer. In April 2005, he was awarded the Saudi Arabian King Faisal International Prize for medicine jointly with Peto for their work on diseases related to smoking. He was also awarded honorary degrees by thirteen different universities.

He died on 24 July, 2005, at the John Radcliffe Hospital in Oxford after a short illness.

Bibliography

  • Doll R, Hill AB. (1950) Smoking and carcinoma of the lung. Preliminary report, British Medical Journal, 2: 739-748.
  • Doll R, Jones, FA. (1951) Occupational factors in the aetiology of gastric and duodenal ulcers, with an estimate of their incidence in the general population. Spec Rep Ser Med Res Counc. London, HM Stationery Office.
  • Doll R, Hill AB. (1954) The mortality of doctors in relation to their smoking habits. British Medical Journal, 228:1451-5.
  • Doll, R (2002) Proof of Causality: Deduction from Epidemiological Observation (Fisher Memorial Lecture), Perspectives in Biology and Medicine, Volume 45, Number 4, pp. 499-515. Excerpt
  • Doll R, Peto R, Boreham J, Sutherland I. (2004) Mortality in relation to smoking: 50 years' observation on male British doctors. British Medical Journal, ;328:1519-33. PMID 15213107.


Source

External links

Retrieved from "http://en.freepedia.org/Richard_Doll.html"


Views
Personal tools
In other languages
Similar Links